Bleomycin toxicity post injection into craniopharyngioma
نویسندگان
چکیده
منابع مشابه
Outcome of postoperative intratumoral bleomycin injection for cystic craniopharyngioma.
Total excision is a treatment of choice in preventing the relapse of craniopharyngioma, but for tumors involving an extensive area, it is often associated with an increased risk of complications. We have performed a partial or subtotal tumor removal followed by repeated injection of bleomycin into the remaining tumor through a subcutaneous reservoir as postoperative adjuvant therapy. A retrospe...
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Diffuse pulmonary fibrosis is associated with bleomycin administration to humans. The sequential reactions of lung cells to this drug have now been investigated in mice following injection of 20 mg/kg bleomycin twice per week for 4 to 8 weeks. Cytoplasmic and subendothelial edema was first observed in large vessels and by 4 weeks involved the capillaries. The reaction in many animals did not pr...
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Bleomycin is known to cause double strand breaks in vitro. Little is known, however, about its mechanism of genotoxicity in vivo. One way to probe the mechanism of genotoxicity of a DNA damaging agent in vivo is to compare the relative sensitivities of a wild type Escherichia coli strain to a panel of isogenic repair deficient mutants. If the pathway defective in the mutant is known (e.g., base...
متن کاملUltrastructural study of pulmonary bleomycin toxicity.
Ultrastructural manifestations of bleomycin A2 toxicity in the human lung were studied in three patients. In addition to the appearance of nucleolar fibrillar centers, an increase in membranous, beaded, and granular nuclear bodies was found in nuclei of type 1, type 2 alveolar epithelial cells, and interstitial fibroblasts in all treated patients. Few such nuclear bodies were found in specimens...
متن کاملPost-operative implantation metastasis of craniopharyngioma: a case report.
Craniopharyngiomas are histologically benign epithelial tumours arising from squamous epithelial remnants of Rathke's pouch, which have a tendency to invade surrounding structures and recur after apparently complete resection. They represent the most frequent non-glial tumour in children, accounting for approximately 5% of paediatric brain neoplasms. Total resection of a craniopharyngioma may b...
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ژورنال
عنوان ژورنال: South African Journal of Radiology
سال: 2012
ISSN: 2078-6778,1027-202X
DOI: 10.4102/sajr.v16i1.227